Four strategic documents on the key themes confronted by the EU-funded EpiSouth Network to enhance surveillance of communicable diseases in the Mediterranean region (2006-2010). These are: 1. Training in Public Health and Applied Epidemiology; 2. Epidemic Intelligence & Cross-Border; 3. Vaccine Preventable Diseases and Migrant Population; 4. Epidemiology and Preparedness to Cross-Border Emerging Zoonoses. Each document is structured around a sequence of topics – evidence of the problem to be addressed, scientific rationale for action, objectives and framework, major stakeholders and targets, activities, achievements and lessons learned, expected outcomes and proposed strategy and recommendations.